人参皂苷CK对重症急性胰腺炎大鼠肝功能和免疫作用的影响

Study of ginsenoside compound K on the effect of immunity and liver function in rats with severe acute pancreatitis

目的探讨人参皂苷CK对重症急性胰腺炎(SAP)大鼠肝功能和免疫作用的影响。方法将46只SAP大鼠随机分为实验组和对照组各23只,对照组采用常规肠内营养和治疗方案,实验组在常规治疗方案基础上采用人参皂苷CK,观察两组大鼠肝功能变化和对免疫功能的影响。结果两组SAP大鼠治疗3、7 d后分别检测血白细胞计数、肝功能(谷丙转氨酶、谷草转氨酶和谷氨酰转肽酶、白蛋白)和免疫功能T细胞亚群(CD_3、CD_4和CD_8阳性细胞数及CD_4/CD_8比值)变化,实验组各项指标均优于对照组(P<0.05)。结论人参皂苷CK作为治疗SAP的辅助手段,具有肝脏保护作用和提高免疫功能。

Objective To study the effect of the ginsenoside compound K（CK） on the function of liver and immunity in rats with severe acute pancreatitis（SAP）. Methods Twenty-three rats with severe acute pancreatitis were treated by ginsenoside CK as the experimental group and 23 rats in the control group received normal SAP treatment. The changes of liver function indexes （ AST, ALT, GGT and ALB） and immunity function indexes such as T cell （ CD3 , CD4 , CD8 cell and CD4/CD8 ） after the SAP rats received treatment in 3 days and 7days were determined. Results Compared with the control group, the plasma liver function index （ AST, ALT, GGT, ALB and STB） levels and the immunity T cell function index（ CD3 , CD4 , CD8 cell and CD4/CD8 ）levels were increased in 3 days and 7 days and there was significant difference （ P 〈 0. 05 ）. Conclusion Ginsenoside CK therapy can effectively protect the function of the liver and immunity in rats with severe acute pancreatitis, and also improve their overall condition. It was an important auxiliary treatment for SAP rats, and it＇ s worthy of deep research in the future.