胃肠外营养支持在癌症晚期患者中的应用

Application of Parenteral Nutrition Support in Patients with Terminal Cancer

目的:探讨胃肠外营养支持在癌症晚期患者中的应用效果。方法:将选取的168例癌症晚期患者随机分为2组,观察组给予静脉营养,对照组常规治疗,观察并比较2组患者的营养状况、机体免疫情况、生活质量情况。结果:治疗3w后,观察组的血清白蛋白、血清总蛋白、血红蛋白显著高于治疗前,差异具有统计学意义(P<0.05);对照组治疗前后的血清白蛋白、血清总蛋白、血红蛋白差异没有统计学意义(P>0.05);观察组的血清白蛋白、血清总蛋白、血红蛋白显著高于对照组(P<0.05);治疗3w后,观察组IgA、IgM、IgG、CD3^+、CD3^+/CD4^+、CD4^+/CD8^+显著高于治疗前(P<0.05);对照组治疗前后IgA、IgM、IgG、CD3^+、CD3^+/CD4^+、CD4^+/CD8^+差异均没有统计学意义(P>0.05);观察组IgA、IgM、IgG、CD3^+、CD3^+/CD4^+、CD4^+/CD8^+显著高于对照组(P<0.05);治疗3w后,观察组QOL评分显著高于治疗前(P<0.05);对照组治疗前后QOL评分差异没有统计学意义(P>0.05);观察组QOL评分显著高于对照组(P<0.05)。结论:胃肠外营养支持有利于改善癌症晚期患者生活质量和癌症晚期营养状况,有利于改善和进一步预防癌症晚期患者机体免疫力的进一步下降。

[Objective] To investigate the effeet of parenteral nutrition support in terminal cancer patients. [Method] Totally 168 patients with terminal cancer were randomly divided into two groups. The observation group was given intravenous nutrition, and the control group was treated routinely. The nutritional status, immune status, and quality of life of the two groups were observed and compared. [Result] The ser- um albumin, serum total protein and hemoglobin were significantly higher in the observation group than in the treatment group after 3 weeks of treatment, the difference was statistically significant （ P 〈 0. 05） . There was no statistical difference in serum albumin, serum total pro- tein and hemoglobin between the two groups before and after treatment （ P 〉 0.05 ） . Serum albmnin, serum total protein and hemoglobin were significantly higher in the observation group than in the control group after 3 weeks of treamlent （P 〈 0.05） . IgA, IgM, IgG, CD3 ＋ , CD3 ＋/CD4 ＋ , and CD4 ＋/CD8 ＋ in the observation group after 3 weeks of treatment was significantly higher than before treatment （ P 〈 0.05 ） . Before and after treatment, IgA, IgM, IgG, CD3 ＋ , CD3 ＋/CD4 ＋ , and CD4 ＋/CD8 ＋ were not significantly different in the con- trol group （P〉0.05） .After 3 weeks of treatment, IgA, IgM, IgG, CD3＋, CD3＋/CD4＋, and CD4＋/CD8＋levels were significantly higher in the observation group than those in the control group （P 〈 0. 05 ） . QOL scores were significantly higher in the observation group than in the treatment group after 3 weeks of treamlent （ P 〈 0.05 ） . Differences in QOL scores between the control group and the control group were not statistically significant （ P 〉 0. 05 ） . After 3 weeks of treatment, QOL scores in the observation group were significantly higher than those in the control group （P 〈 0. 05） . [Conclusion] Parenteral nutrition support is beneficial to improve the quality of life of patients with terminal cancer and the advanced nutritional status of cancer, and also improve and further prevent the further decline of body immunity in terminal cancer patients.