翻译控制肿瘤蛋白的生物学功能及其在肝细胞癌发生发展中的作用

Biological function of translationally controlled tumor protein and its role in the development and progression of hepatocellular carcinoma

翻译控制肿瘤蛋白(TCTP)广泛表达于绝大多数动植物细胞内,参与多种生理学活动。研究发现TCTP在肝癌组织中的表达量明显高于正常组织。介绍了TCTP的主要生物学功能,包括促进细胞生长和发育、调节细胞周期、抑制细胞凋亡、减轻细胞应激反应、调节炎症反应等。简述了TCTP在肝细胞癌(HCC)的发生发展中,除了改变细胞周期、抑制细胞凋亡以外,还可通过诱导细胞有丝分裂缺陷、诱导染色体不稳定性、介导炎症反应与肝纤维化,促进HCC的发生发展。认为TCTP可以作为HCC早期诊断的潜在指标,靶向降低TCTP表达水平有望成为一种新的HCC治疗方法。

Translationally controlled tumor protein（ TCTP） is widely expressed in most animal and plant cells and is involved in various physiological activities. Studies have shown that liver cancer tissue has significantly higher expression of TCTP than normal tissue. This article introduces the main biological functions of TCTP,such as promoting cell growth and development,regulating cell cycle,inhibiting cell apoptosis,reducing cell stress response,and regulating inflammatory response. Besides changing cell cycle and inhibiting cell apoptosis,TCTP can also induce mitotic defects and chromosomal instability,mediate inflammatory response and hepatic fibrosis,and thus promote the development and progression of hepatocellular carcinoma（ HCC）. It is pointed out that TCTP might be used as a potential marker for the early diagnosis of HCC,and targeted reduction of TCTP expression might be a new method for the treatment of HCC.