聚三亚甲基碳酸酯的体外降解性能

Degradability of poly(trimethylene carbonate) in vitro

背景:目前输卵管栓塞器具因为金属质地存在着多种弊端,研究生物降解材料聚三亚甲基碳酸酯,在输卵管栓塞材料领域寻找突破点具有重要意义。目的:观察聚三亚甲基碳酸酯的降解性能,论证其作为输卵管栓塞材料的可能性。方法:选取不同相对分子质量的聚三亚甲基碳酸酯,分别浸泡在磷酸盐缓冲液和脂肪酶溶液中,37℃轻柔振动。定期观察试样的形态、失重率、数均相对分子质量和降解液的p H值,对聚三亚甲基碳酸酯的降解性能进行评价。结果与结论:(1)聚三亚甲基碳酸酯的体外降解模式为表面溶蚀降解,降解产物不含酸性化合物;(2)脂肪酶能加速降解进程,但样品的形状和尺寸是影响相对分子质量下降速率的主要因素;(3)初始相对分子质量影响其降解速率和尺寸稳定性:相对分子质量越大,形状保持率越高,但质量损失越快,反之相对分子质量越小,质量损失越慢,但变形严重;(4)结果显示:选择适合的相对分子质量或通过共聚等手段调节其性能,聚三亚甲基碳酸酯有望用于输卵管栓塞材料。

BACKGROUND： At present, the fallopian tube embolization devices have many malpractices because of the metal texture. Poly（trimethylene carbonate）, a biodegradable material, is introduced to find a breakthrough in the field of tubal embolism materials. OBJECTIVE： To observe the degradation behavior of poly（trimethylene carbonate） and to demonstrate the possibility of its use as a tubal embolization material. METHODS： Poly（trimethylene carbonate） with different relative molecular weight was soaked in phosphate bufferand lipase solution at 37 oC with gently shaking. The degradation behavior of poly（trimethylene carbonate） was evaluated by observing the morphology, mass loss, relative molecular weight of the samples and the pH value of the degradation solution regularly. RESULTS AND CONCLUSION： Poly（trimethylene carbonate） exhibited surface erosion degradation in vitro and the degradation products did not contain acid compounds. Lipase could accelerate the degradation process, but the shape and size of the samples were the main factors that affected the decline rate of molecular weight. The molecular weight of the samples affected the degradation rate and dimensional stability： the larger the relative molecular weight, the higher shape retention rate, but the faster mass loss; the smaller the relative molecular weight, the slower mass loss, but the more serious deformation. Therefore, poly（trimethylene carbonate） is expected to be used for fallopian tube embolization materials by selecting suitable molecular weight or adjusting its properties by copolymerization.