动脉粥样硬化性肾血管病经皮介入治疗疗效的预测指标

Predictors for Endovascular Stenting in Atherosclerosis Renovascular Disease

近年来,动脉粥样硬化性肾血管病患者中接受介入治疗者比例迅速增加,而最近公布的多个大型随机对照临床试验并未得到介入加药物治疗的阳性结果。纳入研究对象的选择偏移可能是造成阴性结果的主因之一。选择合理的预测指标,筛选出可能从介入治疗中获益的人群,就成为该领域研究的重点。目前对术前预测动脉粥样硬化性肾血管病介入治疗效果指标的研究主要集中在肾功能损伤程度和动脉狭窄功能学评价两个方面。现从以上方面对目前关于预测指标的研究现状做一综述。

In recent years, there has been a rapid rise in the number of percutaneous interventions for patients who suffer from atherosclerosis renovascular disease. Several recent randomized clinical trials have failed to demonstrate the major benefits of endovascular stenting for renal artery stenosis in addition to optimal medical therapy. The selection bias of patients may be one of the main causes for the negative results. Predictors screening patients who are more likely to benefit from percutaneous intervention are the focus of this field. At present, the research concerning predictors are mainly focused on the degree of renal function injury and the confirmation of the severity of arterial stenosis. This review analyzes the predictors from the above two aspects.