高原肺动脉高压发病机制研究进展

Research Progress in Pathogenesis of High Altitude Pulmonary Hypertension

高原肺动脉高压主要是由于高原习服不适应或不良适应而产生的高原疾病并发症。高原低氧环境下,低氧导致肺血管收缩,持续低氧能够诱导低氧性肺动脉高压的产生和发展。慢性低氧造成肺血管重构和右心室肥厚等病理生理现象,进而会导致肺水肿、脑水肿等高原病。因此,明确高原性肺动脉高压发病机理为高原病的预防和治疗奠定基础。现就近几年对高原性/低氧肺动脉高压发病机制方面的相关研究进行综述。

High altitude pulmonary hypertension is mainly caused by the complications of plateau disease due to maladjustment of high altitude acclimatization. In low oxygen environment, hypoxia causes pulmonary vasoconstriction, and sustained hypoxia can induce the production and development of hypoxie pulmonary hypertension. Chronic hypoxia causes pulmonary vascular remodeling and right ventricular hypertrophy, and other pathophysiological phenomena, which in turn can lead to pulmonary edema, brain edema and other high altitude diseases. Therefore, making the pathogenesis of high primary pulmonary hypertension clearly lays a foundation for the prevention and treatment of plateau diseases. In this paper, we reviewed the related researches on the pathogenesis of high altitude/hypoxia pulmonary hypertension in recent years.