鞘氨醇激酶-2与疾病相关性的研究进展

Relationship between sphingosine kinase 2 and diseases:research advances

鞘氨醇激酶(SPHK)是生物体内催化鞘氨醇转化为生物活性物质鞘氨醇-1-磷酸(S1P)的关键酶,其体内表达或活性的上调与下调,与许多疾病如癌症、感染和炎症等的发生发展密切相关。该酶目前在人体主要有SPHK1和SPHK2两个亚型,两者结构虽非常相似,但SPHK2生理功能更复杂,相关研究直到近年来才逐渐被报道。目前人们对SPHK2研究尚未透彻,但其可能成为许多疾病治疗靶点的巨大潜力吸引很多学者正在不断进行更多探索,目前已发现抑制SPHK2可有效干预癌症和炎症等疾病。本文将对SPHK2与疾病发生发展及治疗的研究进展进行简要概述。

Sphingosine kinase（SPHK）is the key enzyme that catalyzes the transformation of sphingosine into its bioactive form of sphingosine-1-phosphate（S1 P）in body. The upregulation and downregulation of expression or activities of SPHK are related to the occurrence and development of many diseases,including cancer,infection and inflammation. The human SPHK mainly involves two subtypes：SPHK1 and SPHK2,both with closely similar structures. However,SPHK2 displays more complicated physiological functions and related research has been reported only in the recent few years. Although the understanding about SPHK2 is still limited,more and more research interest has focused on the potential role of SPHK2 on the treatment of diseases, and it has been known that some diseases like cancer and inflammation could be effectively interfered by inhibiting SPHK2. This review briefly summarizes the research development of SPHK2 in relation with diseases,including the generation and development of diseases as well as their therapies.