应用洛铂体腔热灌注联合体外高频深部热疗治疗晚期恶性胸腹水的疗效观察

Observation of curative effect of Lobaplatin hyperthermic perfusion intraperitoneal combined with extracorporeal high frequency deep thermotherapy in the treatment of advanced malignant pleural effusion and ascites

目的探讨晚期恶性胸腹水患者应用洛铂体腔热灌注联合体外高频深部热疗治疗的临床效果。方法 108例晚期恶性胸腹水患者,随机分为参照组和试验组,每组54例。参照组患者给予顺铂体腔热灌注治疗,试验组患者给予洛铂体腔热灌注联合体外高频深部热疗治疗。比较两组临床疗效、生活质量及不良反应发生情况。结果试验组临床总有效率为90.74%,明显高于参照组的72.22%,差异有统计学意义(P<0.05)。两组患者治疗后躯体功能、心理功能、社会功能、物质功能评分均明显高于本组治疗前,且试验组明显高于参照组,差异有统计学意义(P<0.05)。试验组不良反应发生率为11.11%,明显低于参照组的29.63%,差异有统计学意义(P<0.05)。结论晚期恶性胸腹水患者应用洛铂体腔热灌注联合体外高频深部热疗治疗的临床效果更加显著,不良反应少,具有安全、高效的特点,值得临床推广应用。

Objective To explore the clinical effect of Lobaplatin hyperthermic perfusion intraperitoneal combined with extracorporeal high frequency deep thermotherapy in the treatment of advanced malignant pleural effusion and ascites.Methods A total of 108 patients with advanced malignant pleural effusion and ascites were randomly divided into the reference group and the experimental group,54 cases in each group.The reference group was treated with Lobaplatin hyperthermic perfusion intraperitoneal,and the experimental group was given Lobaplatin hyperthermic perfusion intraperitoneal combined with extracorporeal high frequency deep thermotherapy.The clinical efficacy,quality of life and the incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the experimental group was 90.74%,which was significantly higher than 72.22% of the control group,the difference was statistically significant（P〈0. 05）.The scores of body function,psychological function,social function and material function in the two groups after treatment were significantly higher than those before treatment,and those in the experimental group weresignificantly higher than the reference group,the differences were statistically significant（P〈0. 05）.The incidence of adverse reactions in the experimental group was 11.11%,which was significantly lower than 29.63% in the reference group,the difference was statistically significant（P〈0. 05）.Conclusion The clinical effect of Lobaplatin hyperthermic perfusion intraperitoneal combined with extracorporeal high frequency deep thermotherapy in the treatment of advanced malignant pleural effusion and ascites is more significant,less adverse reactions,safe and efficient,worthy of clinical application.