温胃方联合三联疗法治疗胃溃疡(虚寒)随机平行对照研究

Randomized Controlled Parallel Study of Wenwei Decoction(温胃方) combined with Triple Therapy in Treatment of Gastric Ulcer(Xuhan/虚寒)

[目的]观察温胃方联合三联疗法治疗胃溃疡(虚寒)疗效。[方法]使用随机平行对照方法,将102例门诊患者按按就诊顺序号随机分为两组,饮食控制。对照组51例三联疗法:奥美拉唑,20mg/次,1~2次/d,晨起吞服或早晚分次;阿莫西林,0.5g/次,1次/6~8h,总剂量≤4g/d;克拉霉素,250mg/次,2次/d。治疗组51例温胃方(白术、瓦楞子煅、白及各15g,高良姜、桂枝各9g,甘草、砂仁、姜干各6g,麦芽、茯苓、陈皮各12g,党参20g,大枣5枚),水煎100m L,2次/d;三联疗法同对照组。连续治疗6周为1疗程。观测临床症状、溃疡病灶、不良反应。治疗1疗程(6周),判定疗效。随访1年,观测复发率。[结果]治疗组痊愈30例,显效11例,有效9例,无效1例,总有效率98.04%;对照组痊愈15例,显效14例,有效12例,无效10例,总有效率80.39%;治疗组疗效优于对照组(P<0.05)。复发率治疗组6.67%低于对照组33.33%(P<0.05)。[结论]温胃方联合三联疗法治疗胃溃疡(虚寒),疗效满意,无严重不良反应,值得推广。

[Objective] To observe the therapeutic effect of Wenwei decoction combined with triple therapy on gastric ulcer （Xuhan）. [Methods] Using random parallel control method, 102 outpatients were randomly divided into two groups according to the order number, diet control. In the control group, 51 cases of triple therapy： omeprazole, 20 mg/times, 1～2 times/d, morning swallowing or morning and evening; amoxicillin, 0.5 g/times, 1 times/6 to 8 h, total dose of less than 4 g/d; clarithromycin, 250 mg/times, 2/d. In the treatment group, 51 cases（baizhu, Duanwalengzi, Baiji each 15 g, Gaoiangjiang, Guizhi each 9 g, Gancao, Sharen, Ganjing each 6 g, Maiya, Fuling,Chenpi each 12 g, Dangshen 20 g, Dazao 5）, water decoction 100 m L, 2 times/d, and triple therapy with the control group. Continuous treatment for 6 weeks was the 1 course of treatment. Clinical symptoms, ulcer foci and adverse reactions were observed. The 1 course of treatment（6 weeks） was treated and the curative effect was determined. The recurrence rate was observed for 1 years. [Results] The treatment group recovered 30 cases, effective 11 cases, effective 9 cases, invalid 1 cases, total effective rate 98.04%, the control group cured 15 cases, 14 cases, effective 12 cases, invalid 10 cases, total effective 80.39%, the treatment group was better than the control group（P〈0.05）. The recurrence rate of the treatment group was 6.67% lower than that of the control group 33.33%（P〈0.05）. [Conclusion] The treatment of gastric ulcer（Xuhan） with Wenwei decoction and triple therapy has satisfactory curative effect, no serious adverse reactions, and is worthy of promotion.