冠心病稳定型心绞痛患者血清白介素6水平与中医证候要素痰、瘀的相关性研究

Study on the Correlation between TCM Syndrome Elements and the Level of Interleukin-6 of CHD Patients with Stable Angina Pectoris

目的:探讨冠心病稳定型心绞痛患者血清白细胞介素6(IL-6)水平与中医证候要素痰、瘀的相关性,为冠心病中医辨证提供更多客观化依据。方法:对122例冠心病稳定型心绞痛患者的中医证候要素积分进行统计,并测量患者血清IL-6水平,分析血清IL-6水平与中医证候要素痰、瘀之间的相关性。结果:在IL-6水平方面,冠心病有"痰"组患者高于无"痰"组(P=0.00),有"瘀"组高于无"瘀"组(P=0.00),"痰瘀互结"组高于"非痰非瘀"组、"痰浊"组(P=0.00)及"瘀血"组(P=0.005),"痰浊"组高于"非痰非瘀"(P=0.002)。IL-6水平与痰证、瘀证积分呈高度正相关。IL-6水平与痰证证素积分存在线性回归关系;与瘀证证素积分存在曲线回归关系。结论:1)冠心病患者血清IL-6水平与痰、瘀密切相关;当两种证候要素兼夹存在时,IL-6的水平高于痰瘀皆无,或仅有痰、瘀中的一种证候要素存在时。2)"瘀血"组与"痰浊"组比较,IL-6水平2组间不存在统计学差异,因此两者的鉴别诊断方向需要进一步研究。

Objective： To provide more objective evidence for TCM differentiation of coronary heart disease （CHD） by exploring the correlation of interleukin-6 （IL-6） in the serum of CHD patients with stable angina pectoris （SAP） with TCM syndrome elements such as phlegm and blood stasis. Methods： TCM syndrome elements scores of 122 CHD patients with SAP were counted, and the levels of IL-6 in the serum of the patients were detected, the correlation of the levels of II.,-6 in the serum with TCM syndrome elements phlegm was analyzed. Results： In the aspects oflL-6 levels, the phlegm group was higher than no phlegm group obviously （P=-0.00）, the blood stasis group was higher than no blood stasis group remarkably （P=-0.00）, the group of intermingled phlegm and blood stasis was higher than no phlegm and blood stasis group, phlegm turbidity group（P=0.00） and blood stasis group（P=0.005）, phlegm turbidity group was higher than no phlegm and blood stasis group （P=-0.002） clearly. The level of IL-6 was positively correlated to phlegm syndrome and blood stasis syndrome. Linear regression relationship existed between IL-6 level and phlegm syndrome scores, while curve regression relationship existed between IL-6 level and blood stasis syndrome scores. Conclusion： 1） The level of IL-6 in the serum of CHD patients is closely related to phlegm and blood stasis; when two syndrome elements exist simultaneously, the level of IL-6 is higher than that of the patients without phlegm and blood stasis or with only one pathological factor. 2） When blood stasis group is compared with phlegm turbidity group, there is no statistical difference in the level of IL-6 between both groups, hence, the direction of identification and diagnosis for both factors is in the need of further study.