非小细胞肺癌淋巴结微转移的研究进展

Research Progress of Lymph Node Micrometastasis in Non-small Cell Lung Cancer

肺癌在我国是发病率和死亡率最高的恶性肿瘤,肿瘤发生转移是产生这种现象的重要因素。随着科学技术的发展,外科治疗对肺癌的效果有所提高。与此同时,分子靶向治疗的问世使肺癌的治疗达到了一个新的高度。但是,即使肿瘤在早期得到了完整切除,术后复发的可能性仍较高,这可能与肿瘤发生了淋巴结微转移(micrometastasis)有关。微转移逐渐成为现代医学研究的热点之一,相关的研究逐渐深入,但淋巴结微转移对肺癌手术方式的选择、病理分期及预后等方面的影响尚存在争议。本文综合论述了非小细胞肺癌(non-small cell lung cancer,NSCLC)淋巴结微转移的研究进展。

The incidence and mortality of lung cancer rank top in China. One important factor is the occurrence of metastasis. With the development of science technology, the effect of surgical treatment on lung cancer is improved. Moreover, the use of targeted therapy has achieved a new height for the treatment of lung cancer. However, the recurrence rate remains high even the tumor was completely resected at early stage. The occurrence of lymph node micrometastasis is considered as one of the plausible explanations. The difficulty indetecting micrometastasis has been greatly reduced. Although studies dig deeper into the lymph node micrometastasis, there are still some controversies including the selection of surgical procedures, the pathological staging and prognosis about patients with lymph node micrometastasis. This review manages to generalize the latest research progress of lymph node micrometastasis.