^(99)Tc^m-MIBI SPECT/CT双时相显像联合血清甲状旁腺激素测定对原发性甲状旁腺功能亢进症的诊断价值

The Diagnostic Value of ^(99)Tc^m-MIBI SPECT/CT Dural-phase Scanning Combined with Serum Parathroid Hormone Measurement in Hyperparathyroidism

目的探讨^(99)Tc^m-MIBI SPECT/CT双时相断层显像联合血清甲状旁腺激素(PTH)在诊断原发性甲状旁腺功能亢进症(PHPT)中的价值。方法回顾性分析63例疑似PHPT患者的^(99)Tc^m-MIBI SPECT/CT双时相显像与血清PTH的结果,并与术后病理结果对照,比较分析^(99)Tc^m-MIBI SPECT/CT双时相显像、血清PTH检测及两者联合诊断三种方法的诊断效能。结果^(99)Tc^m-MIBI SPECT/CT双时相显像、血清PTH检测及两种方法联合诊断的灵敏度分别为80.95%、71.43%、97.62%,特异性分别为80.95%、57.14%、90.48%,准确率分别为80.95%、66.67%、95.24%。结论^(99)Tc^m-MIBI SPECT/CT双时相显像联合血清PTH测定较单一检查可明显提高诊断PHPT的灵敏度和准确率,有重要的临床应用价值。

Objective To assess the value of 99Tcm-MIBI SPECT/CT dural-phase scanning combined with parathyroid hormone（PTH） measurement in diagnosis of primary hyperparathyroidism（PHPT）. Methods The results of 99Tcm-MIBI SPECT/CT dural-phase scanning and serum PTH measurement in sixty-three patients with suspected PHPT were retrospectively analyzed. All results were compared with pathological findings. The diagnostic efficacy indicators of 99Tcm-MIBI SPECT/CT dural-phase scanning,serum PTH measurement and 99Tcm-MIBI SPECT/CT dural-phase scanning combined with PTH measurement in PHPT were compared and analyzed. Results The sensitivity,specificity and accuracy of 99Tcm-MIBI SPECT/CT dural-phase scanning,serum PTH measurement and combined methods were 80. 95%,71. 43%,97. 62%; 80. 95%,57. 14%,90. 48%; and 80. 95%,66. 67%,95. 24%. Conclusion 99Tcm-MIBI SPECT/CT dural-phase scanning combined with PTH measurement have higher sensitivity and accuracy than single method and combined methods have significant clinical value in the diagnosis of PHPT.