贝伐单抗联合TP方案治疗晚期HER2阴性乳腺癌的临床疗效及对患者相关细胞因子水平的影响

The Clinical Efficacy and the Effect on the Level of Cytokines in Patients with Advanced Breast Cancer Treated by the Combination of Bevacizumab and TP Regimen

目的探讨贝伐单抗联合紫杉醇与顺铂联合化疗方案(TP)治疗晚期乳腺癌的临床疗效及对患者相关细胞因子水平的影响。方法入选2015年3月至2017年3月间于我院治疗的晚期乳腺癌患者60例,随机分成对照组(n=30)和观察组(n=30)。对照组患者给予TP方案治疗,观察组患者在TP方案化疗的基础加用贝伐单抗治疗。两组均以3周为一疗程,连续治疗两个疗程后根据改良版实体瘤疗效评价标准(mRCIST)评价疗效,观察并记录治疗前后疾病相关因子水平变化情况及治疗期间的不良反应发生情况。结果观察组患者治疗后的临床收益率(CBR)显著优于对照组(P<0.05);治疗后两组患者血管内皮生长因子(VEGF)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平均明显改善,且观察组显著优于对照组(P<0.05);治疗过程中两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论贝伐单抗联合TP方案治疗晚期乳腺癌的疗效显著,能够有效改善相关细胞因子水平,且安全可靠,值得临床推广。

Objective To investigate the clinical efficacy of bevacizumab combined with TP regimen in the treatment of advanced breast cancer and effect on cytokines in patients. Methods 60 patients with advanced breast cancer from March 2015 to March 2017 in our hospital were randomly divided into control group（n =30） and observation group（n = 30）. Control group was treated with TP regimen based on the observation of treatment,and TP chemotherapy group were given with bevacizumab treatment. Three weeks were set as a course of treatment for two groups. After two months continuous treatment,the efficacy was evaluated,observed and recorded according to the curative effect of the improved version of evaluation criteria in solid tumors（mRCIST）. Results The clinical rate of return（CBR） in the observation group was significantly higher than that in the control group（P〈0. 05）. After treatment,vascular endothelial growth factor（VEGF）,interleukin-4（IL-4）,and interleukin-10（IL-10） were observed in both groups. Tumor necrosis factor-α（TNF-α）level was significantly improved in the observation group than that in the control group（P〈0. 05）.There was no significant difference in the incidence of adverse reactions between two groups in the course of treatment（P〉0. 05）. Conclusion The efficacy of bevacizumab combined with TP regimen in the treatment of advanced breast cancer is significant. It can effectively improve the level of cytokines and is safe and reliable.It is worthy of clinical application.