高尿酸血症与H型高血压的相关性研究

Association between hyperuricemia and H type hypertension

目的探讨高尿酸血症分别与单纯高血压、高同型半胱氨酸血症(h-HCY)以及H型高血压患病之间的相关性。方法选取2017年3月-2018年3月10 344名自行前往中南大学湘雅医院健康管理中心进行健康体检的人群作为研究对象,以研究高尿酸血症与单纯高血压、h-HCY及H型高血压之间的相关性。采用多元Logistic回归分析分别计算高尿酸血症组与非高尿酸血症组之间高血压、h-HCY以及H型高血压患病率的比值比(OR)及其95%可信区间(CI)。结果多因素校正后的结果显示,与非高尿酸血症组相比,高尿酸血症人群中患单纯高血压的概率的OR(95%CI)为1.217(95%CI:0.901～1.645,P=0.200)。与正常对照组相比,高尿酸血症人群中患h-HCY的概率的OR(95%CI)为1.843(95%CI:1.581～2.149,P<0.001)。和正常对照组相比较,高尿酸血症人群中患H型高血压的概率的OR(95%CI)为2.100(95%CI:1.739～2.536,P<0.001)。结论该横断面研究证实高尿酸血症与H型高血压、h-HCY患病呈正相关,与单纯高血压患病不相关。

【Objective】To investigate the relationships between hyperuricemia with hypertension, hyperhomocysteinemia and H type hypertension.【Methods】This study included 10344 subjects who underwent routine checkups in the Department of Health Examination Center of Xiangya Hospital, Central South University between March 2017 and March 2018. A multivariable model was adopted in the Logistic analyses for calculating the odds ratios（ORs） with 95% confidence intervals（CIs） for the relationships between hyperuricemia with hypertension, hyperhomocysteinemia and H type hypertension.【Results】Compared with the nonhyperuricemia group, no significant association between hyperuricemia and hypertension was observed in the multi-variable model（OR=1.217, 95%CI： 0.901～1.645, P =0.200）. Significant associations between hyperuricemia with hyperhomocysteinemia（OR=1.843, 95%CI： 1.581～2.149, P〈0.001） and H type hypertension（OR=2.100, 95%CI： 1.739～2.536, P〈0.001） were observed in the multivariable model.【Conclusion】This cross-sectional study suggested that hyperuricemia was significantly associated with H type hypertension and hyperhomocysteinemia, but not with hypertension.