VEGF、CA125和HE4联合检测对子宫内膜异位症的诊断价值

Diagnostic value of Combined Detection of Serum VEGF, CA125 and HE4 for Endom etriosis

目的:探讨VEGF、CA125和HE4在子宫内膜异位症(endometriosis,EMT)患者血清中的表达及其临床诊断价值。方法:应用酶联免疫吸附法检测研究组35例EMT患者和对照组35例正常健康女性血清VEGF、CA125和HE4浓度,并对两组数值进行统计学分析。结果:研究组患者血清VEGF、CA125和HE4浓度明显高于对照组,差异具有统计学意义(P<0.05);VEGF、CA125、HE4以及三种指标联合对EMT诊断的灵敏度分别为94.29%、68.57%、69.97%、84.29%,特异度分别为60.00%、82.86%、91.43%、97.14%,在ROC曲线下的面积分别为0.813、0.822、0.612和0.909。结论:EMT患者血清VEGF、CA-125和HE4具有显著变化,联合检测VEGF、CA-125和HE4对EMT的诊断有很高的敏感度和特异度,具有重要的临床价值。

Objective To investigate the expression and clinical diagnosis value of VEGF, CA125 and HE4 in the serum of endometriosis（EMT）. Methods The concentrations of serum VEGF, CA125 and HE4 were measured by enzyme linked immunosorbent assay in the two groups and the numerical statistics were analysised. Results The concentrations of serum VEGF, CA125 and HE4 were higher in EMT than the control group and the difference were significant （P＇〈0.05）; The sensitivity of VEGF, CA125, HE4 and the combined were 94.29 %, 68.57 %, 69.97 %, 84.29 % respectively, The specificity was 60.00 %, 82.86 %,91 A3 %, 97.14 % respectively, the areas under ROC curve were 0.813, 0.822, 0.6t2 and 0.909 respectively. Conclusions The differences of serum VEGF, CA-125 and HE4 in EMT patients are significant, there is an important clinical value of combined detection of VEGF, CA-125 and HE4 in the diagnosis of EMT.