摘要
随着神经影像学在精神分裂症中的研究不断发展,对精神分裂症的病因假说相关的神经生化递质也不断深入,谷氨酸作为精神分裂症病因学假说的重要补充,在精神分裂症病理生理机制中有着至关重要的地位。现对磁共振质子波谱的基本原理及其分析首发精神分裂症患者脑中谷氨酸能水平的研究进展作一综述。
With the continuous development of neuroimaging research in schizophrenia, the neurotransmitters related to the etiology of schizophrenia are also deepening. As an important complement to the etiology of schizophrenia, glutamate plays a crucial role in the pathophysiology of schizophrenia. This article mainly introduces the basic principles of magnetic resonance proton spectroscopy and the research progress on analyzing glutamatergic levels in the brain of first-episode schizophrenic patients.
作者
袁念
袁廉
王碧馨
吕笑丽
李哲
杜向东
Yuan Nian;Yuan Lian;Wang Bixin;Lyu Xiaoli;Li Zhe;Du Xiangdong(Suzhou Psychiatric Hospital,the Affiliated Guangji Hospital of Soochow University,Suzhou 215008,China)
出处
《神经疾病与精神卫生》
2018年第5期373-377,共5页
Journal of Neuroscience and Mental Health
基金
苏州市精神疾病临床医学中心(Szzx201509)
苏州市生物精神病学研究重点实验室(SZS201722)
苏州市科教兴卫青年科技项目(kjxw2015032)
关键词
精神分裂症
磁共振质子波谱
谷氨酸
神经生化代谢物
综述
Sehizophrenia
Proton magnetic resorrance stxectroscopy
Glutamic acid
Neurobiochemical metabolites
Review