男性原发性高血压患者血清尿酸与左心房增大的关系研究

Study on the relationship between left atrial diameter with serum uric acid level in male patients with essential hypertension

目的探讨男性原发性高血压患者血清尿酸与左心房增大的关系。方法选取2015年6月至2016年12月广东省人民医院收治的男性原发性高血压患者298例，测量患者肝肾功能、血脂、血压、血糖和尿酸，根据超声心动图检查结果分为左心房增大组及左心房正常组，血清尿酸与左心房增大的关系采用多变量logistic回归分析。结果298例男性原发性高血压患者平均年龄（55．29±8．48）岁，平均尿酸值（488．93±112．46）μmol/L，其中左心房增大患者47例，左心房增大组血清尿酸水平[（512．21±90．82）μmol／L比（474．38±94．26）μmol／L]明显高于左心房正常组（t=9．34，P〈0．001），差异有统计学意义。Pearson相关分析表明血清尿酸与左心房内径呈正相关（r：0．589，P〈0．001）；多因素logistic回归分析血清尿酸是左心房增大的危险因素（OR=1．894，95％CI：1．13，2．69；P〈0．001）。结论男性原发性高血压患者血清尿酸与左心房内径呈正相关，并且是左心房增大的危险因素。

Objective To study the relationship between serum uric acid and left atrial size in male patients with essential hypertension. Methods From June 2015 to December 2016,298 males with essential hypertension in the People＇s Hospital of Guangdong Province were selected. They were divided into normal left atrial group and enlarged left atrial group based on the size of left atrial diameter. The fasting blood glucose, serum lipid, serum uric acid, hepatic and renal function and blood pressure were measured by routine methods, and multivariate logistic regres- sion was used to analyze. Results The average age and serum uric acid level of 298 males with essential hypertension were （55.29 ±8.48） years old and （488.93 ± 112.46） μmol/L. There were 47 cases with enlarged left atrial. The serum uric acid .level in the enlarged left atrial group was significant higher than that in the normal left atrial group [ （512.21 ± 90.82 ） μmol/L vs. （474.38 ± 94.26 ） μmol/L, t = 9.34, P 〈 0. 001 ]. Pearson correlation analysis showed that serum uric acid level was positively associated with left atrial diameter（r = 0.589 ,P 〈0.001 ）. Multiple logistic regression analysis showed that the serum uric acid level was a＇risk factor for enlarged left atrial（ OR = 1. 894, 95% CI： 1.13,2.69 ;P 〈 0. 001 ）. Conclusion Serum uric acid level is positively correlated with left atrial size in male patients with essential hypertension, and is a risk factor for enlarged left atrial.