家族性胃癌研究进展

Progress in research of familial gastric cancer

与散发性胃癌比较,家族性胃癌患者具有肿瘤分化差、发病年龄早和预后不佳的特点,因此,进行早期的遗传学检测对疾病的诊断及预防具有重要的学术价值和临床意义。随着分子生物学和遗传学的发展,人们对家族性胃癌的诊断标准、遗传学基础及分子机制方面有了更为具体的认识。现将家族性胃癌的遗传学方面最新研究进展综述如下,同时对临床方面的防治措施进行讨论下。

Compared with sporadic gastric cancer, familial gastric cancer has poor tumor differentiation, early onset, and poor prognosis. Therefore, the early genetic testing is of important value and clinical significance for the diagnosis and prevention of the disease. With the development of molecular biology and genetics, there has been a better understanding of the diagnostic criteria, genetic basis, and molecular mechanism of familial gastric cancer. This paper summarizes the latest knowledge on the genetic aspects of familial gastric cancer and discusses its prevention and treatment.