小剂量阿司匹林治疗子痫前期高危孕妇的临床效果研究

The clinical study of effect of treating preeclampsia high risk pregnant women with low-dose aspirin

目的分析治疗子痫前期高危孕妇采用小剂量阿司匹林的临床疗效。方法选取我院2015年11月~2017年11月所收治的子痫前期高危孕妇60例,根据孕妇入院时间分为研究组(n=30)和参照组(n=30),参照组孕妇给予常规药物治疗,研究组孕妇在此基础之上给予小剂量阿司匹林治疗,对比2组孕妇治疗前后临床症状变化情况、治疗后的临床效果以及子痫前期发生情况。结果治疗后,研究组孕妇MAP、24h proteinuria、HCG、PLGF改善情况均优于参照组,组间对比统计学意义存在(P<0.05),研究组孕妇剖宫产、出血、流产相对参照组,组间对比差异无统计学意义(P>0.05),子痫前期研究组孕妇发生率3.3%低于参照组孕妇发生率30.0%,组间对比统计学意义存在(P<0.05)。结论治疗子痫前期高危孕妇采用小剂量阿司匹林治疗具有显著临床效果,能够改善孕妇平均动脉压以及尿蛋白水平,对孕妇子痫发生具有明显改善作用。

Objective To discuss the clinical effect of treating preeclampsia high risk pregnant women with low-dose aspirin. Methods Choosed 60 cases of preeclampsia high risk pregnant women from Nov. 2015 to Nov. 2017 to divide into study group and controlled group with 30 cases in each. The controlled group were treated with routine medicince, the study group were treated with low-dose aspirin added. Compared the clinical symptoms, clinical effect and eclampsia in pregnancy of these two groups. Results The results of MAP, 24 h proteinuria, HCG, PLGF of study group were better than controlled group（P〈0.05）. And there was no difference with bleeding and abortion（P〈0.05）. And the incidence of preeclampsia of study group was 3.3%, lower than 30.0% of controlled group（P〈0.05）. Conclusion Using low-dose aspirin to reating preeclampsia high risk pregnant women with effect can improve arterial pressure and PRO protein.