γδT细胞在恶性肿瘤治疗中的作用及其研究进展

The role of γδT-cell in the treatment of malignant tumor and research progress

γδT细胞识别抗原不需要特异性抗原刺激并无MHC限制性,在抗肿瘤免疫中具有连接天然免疫和适应性免疫的作用,是肿瘤细胞免疫治疗强有力的工具。激活的γδT细胞可通过多种途径发挥对肿瘤细胞的细胞毒作用,在体内外均有较好的抗肿瘤效应;作为一种新兴的肿瘤免疫疗法,γδT细胞免疫治疗技术具有良好的应用前景。现就γδT细胞在恶性肿瘤治疗中的作用及其研究进展作一综述。

γδT cell antigen recognition does not require specific antigen stimulation withou MHC restriction,thus it has a natural and adaptive immune response in the anti-tumor immunity.Activation of γδT cells exert cytotoxic effect on tumor cells through various ways which has the potential to serve as a powerful tool in tumor immunotherapy.A large number of studies have shown that γδT cells have good antitumor effect in vitro and in vivo.As a new tumor immunotherapy,γδT cell immunotherapy technology shows a promising application prospect.This article will focus on the role of γδT cells in the treatment of malignant tumors and their research progress.