卵巢癌腹水非细胞成分对肿瘤的影响

Effect of acellular fraction of ovarian cancer ascites on tumor

卵巢癌病死率居妇科肿瘤最高,早期诊断率低,多数初次诊断时即为晚期。超过1/3的卵巢癌以及几乎全部的复发患者伴有腹水的产生。卵巢癌腹水中非细胞成分丰富复杂,包括细胞因子、蛋白质、代谢物和外泌体,形成复杂的腹水肿瘤微环境,影响肿瘤细胞的生物学行为及疾病进展。现就卵巢癌腹水非产细胞成分的种类、对肿瘤细胞及疾病的影响作一概述。

Ovarian cancer has the highest mortality among gynecologic cancers. The rate of early diagnosis is low and most cases have reached an advanced stage at the initial diagnosis. More than one-third of ovarian cancer patients present a large amount of ascites at the time of diagnosis. Acellular fraction of ovarian cancer ascites richly includes cytokines, proteins, metabolites, and exosomes, constitutes a unique and complicated tumor microenvironment, and influences the biological behavior of tumor cells and the progression of the disease. This paper gives an overview of the acellular fraction of ovarian cancer ascites and its effect on tumor.