The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

目的：明确益气养阴法联合化疗是否较单纯使用化疗治疗肺癌在增效、减毒等方面更有优势.方法：从网络数据库中检索2013年1月至2017年1月期间以中医益气养阴为治法联合化疗方案对比单纯化疗治疗肺癌并且运用了随机对照试验研究的国内外文献,然后采用RevMan5.3.5软件对搜集的文献质量进行评价、筛选.结果：成功筛选符合系统评价的文献10篇,总病例691例,治疗组共369例（益气养阴中药＋化疗）,对照组322例（单纯化疗）.Meta分析结果显示治疗组在改善肺癌临床症状方面具有显著统计学差异（P〈0.001）,在实体瘤情况方面、在生活质量改善情况方面、在不良反应发生情况方面两组对比均有显著统计学差异（P〈0.001）.结论：益气养阴法联合化疗能显著改善中晚期肺癌患者的临床症状,减少因化疗引起的毒副反应,提高患者生活质量.

Objective： To evaluate whether herbs of supplementing Qi and nourishing Yin combined with chemotherapy （versus chemotherapy alone） improve survival, increase tumor response, improve performance status or reduce chemotherapy toxicity in patients with lung cancer. Methods： Searching the randomized controlled trials （RCT） studies from the databases （China HowNet database, Wan Fang database, VIP database, Master Thesis and Pubmed） between January 2013 and January 2017. RevMan 5.3 software was used to evaluate the quality of these collected papers. Results： Of 48 potentially relevant publications, 10 randomized studies representing 691 patients met inclusion criteria with 369 cases in the supplementing Qi and nourishing Yin plus Chemotherapy group （Herbs ＋ Chem group） and 322 cases in Chemotherapy group （Chem only group）. There were significant differences between Herbs ＋ Chem group and Chem only group in improving the treatment efficacy and reducing the side effects of chemotherapy （P 〈 0.001 for all）. There were also significant differences between the two groups in tumor response and quality of life （P 〈 0.001 for all）. Conclusion： Herbs of supplementing Qi and nourishing Yin may increase chemotherapy effectiveness, reduce chemotherapy toxicity and improve the quality of life of patients with lung cancer when combined with chemotherapy.