Progress of Alzheimer＇s disease related glucose metabolism regulating hormones and a research perspective in nootropics of herbal medicine

阿尔茨海默病是一种神经退行性疾病,但其发病机制尚不清楚.有证据表明糖尿病与阿尔茨海默病发病有关,而糖尿病发病的的根本原因是糖代谢异常.因此糖代谢调节激素和阿尔茨海默病之间可能存在不可分离的关系.作者综述了糖代谢调节激素与阿尔茨海默病发病机制的相关研究进展,并基于此对益智中药研究提出了新思路.

Alzheimer’s disease as one of the neurodegenerative diseases, its pathological mechanisms still remains unclear. There’s evidence that diabetes is associated with Alzheimer’s disease. However, the fundamental cause of diabetes is abnormal glucose metabolism. There may be an inseparable relationship between glucose metabolism regulating hormones and Alzheimer’s disease. Here, we review the studies that connect the glucose metabolism regulating hormones to Alzheimer’s disease, and that suggest the quality of Alzheimer’s patients is improved by regulating glucose metabolism.