A Meta analysis of characteristics of median nerve and sural nerve injury inpatients with diabetic peripheral neuropathy

目的：对国内外公开发表的通过感觉神经定量检测仪测量糖尿病周围神经病变（Diabetic peripheral neuropathy,DPN）患者正中神经和腓肠神经损伤程度的临床随机对照研究进行荟萃分析,观察DPN患者周围神经损伤的特点.方法：在Pubmed数据库、中国生物医学文献库、维普数据库、中国知网中检索有关感觉神经定量检测与DPN的文献,并评价所有相关的文献;经过仔细阅读文献并提取相关数据;对每个纳入研究中的糖尿病患者在2000Hz、250Hz、5Hz的电流感觉阈值（Current perception threshold,CPT）值与正常对照组CPT值进行对比,各组数据均以均数±标准差（m±s）表示分析的统计量,并进行异质性检验.结果：最终纳入10篇符合标准的文献,患者组1054例,正常组719例.患者组左、右正中神经和左、右腓肠神经在2000Hz、250Hz、5Hz时的CPT值均大于正常对照组（P〈0.05）.结论：纳入荟萃分析的DPN患者左。

Objective： A meta-analysis of randomized trials was performed to assess the injured degree of median nerve andsural nerve in patients with diabetic peripheral neuropathy （DPN）. Methods： we searched Pubmed Database, ChinaBiomedical Literature Database, VIP Database, ChinaNet for studies. Then evaluated these studies in order to findthe researches in line with the requirements of the study; Each relevant research was carefully read to extractrelevant data; The current perception threshold （CPT） value of median nerve and sural nerve were compared at2000Hz, 250Hz and 5Hz between patients with DPN and the normal control group. Results： Finally 10 articles thatmeet the standards were included, with 1054 cases in the patient group and 719 cases in the normal group. The CPTvalues of median nerve and sural nerve at 2000 Hz, 250 Hz and 5 Hz of patients group were higher than those ofnormal control group （P 〈0.05 for all）. Conclusion： Systematic reviews showed that the sensitivity of the mediannerve and sural nerve in DPN patients was generally reduced. Sensory nerve quantitative detector could detectnerve damage early, accurately and monitor the effect treatment in patients with DPN.