期刊文献+

nm23在子宫内膜异位症中的表达与意义探讨

The Expression and Significance of nm23 in Endometriosis
下载PDF
导出
摘要 目的探讨nm23在子宫内膜异位症中的表达与意义。方法选取我院于2012年6月~2017年12月收治的子宫内膜异位症患者38例为研究组,另选取32例正常内膜组织者为对照组。采取免疫组织化学法对两组nm23的表达情况进行比较。结果对照组内膜中nm23的表达率高达90.63%,而研究组内膜中的表达率仅42.11%,显著低于对照组,差异有统计学意义(P<0.05)。结论 nm23在子宫内膜异位症中有重要的作用。 Objective To investigate the expression and significance of nm23 in endometriosis. Methods A total of 38 patients with endometriosis treated in our hospital from June 2012 to December 2017 were selected as the study group, and 32 patients with normal endometrium were selected as the control group. Immunohistochemistry was used to compare the expression of nm23 in both groups. Results The expression rate of nm23 in the endometrium of the control group was as high as 90.63%, while the expression rate in the endometrium of the study group was only 42.11%, which was significantly lower than that of the control group(P〈0.05). Conclusion Nm23 plays an important role in endometriosis.
作者 黄建 郭金强 周伟新 冯春宇 凌学民 Huang Jian;guo Jin-qiang;ZHou Wei-xin;FENG Chun-yu;LING Xue-min(Department of Gynecology,Second People’s Hospital,Longgang District,Shenzhen,Guangdong Province;Department of Ultrasonic diagnosis,second people’s Hospital,Longgang District,Shenzhen City,Guangdong Province;Department of Pathology,Second People’s Hospital,Longgang District,Shenzhen,Guangdong Province)
出处 《实用妇科内分泌电子杂志》 2017年第35期92-93,共2页 Electronic Journal of Practical Gynecological Endocrinology
基金 广东省深圳市龙岗区医疗卫生科技计划项目(20170328144131180)~~
关键词 NM23 子宫内膜异位症 Nm23 Endometriosis
  • 相关文献

参考文献1

二级参考文献17

  • 1李铁臣,孔丽娜,孙青,罗永红,卢林明.子宫内膜异位症中nm23-H1基因表达的意义[J].中国病理生理杂志,2007,23(1):116-119. 被引量:4
  • 2BONOCHER CM, MONTENEGRO ML, ROSA E SILVA JC,et al. Endometriosis and physical exercises:a systematic review [ J ]. Re- prod BiEndocrinol,2014,6(12) :4 -9.
  • 3EMRE A,AKBULUT S, YILMAZ M,et al. An unusual cause of a- cute appendicitis: Appendiceal endometriosis [ J ]. Int J Surg CaseRep,2013,4( 1 ) :54 -57.
  • 4SILVA N, SENANAYAKE H, WADUGE V. Elevated levels of whole blood nickel in a group of Sri Lankan women with endometri- osis : a case control study[ J]. BMC Res Notes,2013,6 : 13.
  • 5STEEG PS, BEVILACQUA G, POZZATYI R, et al. ME. Altered ex- pression of NM23, a gene associated with low tumor metastatic po- tential, during adenovirus2 Ela inhibition of experimental metasta- sis[ J]. Cancer Res, 1988,48:6550 - 6554.
  • 6XI PENG LONG, WU FANG BU, YUAN WANG,et al. Expression of p53 in the Effects of Artesunate on Induction of Apoptosis and Inhibition of Proliferation in Rat Primary Hepatic Stellate Cells [ J ]. PLoS ONE,2011,6 ( 10 ) : e26500.
  • 7HAQUES, YAN X J, ROSEN L, et al. Effects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-in- dependent human B-cell clonal expansion E [ J]. FASEB J,2014, 28:627 - 643.
  • 8JARRETY SG, NOVAK M, HARRIS N, et al. NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of hu- man melanoma[ J. Clin Exp Metastasis,2013,30( 1 ) :25 -36.
  • 9ZHAO RONGZHI, GONG LEI, LI LIN,et al. nm23-H1 is a nega- tive regulator of TGF-131-dependent induction of epithelial-mesen- chymal transition [ J 1. Exp Cell Res,2013,319 (5) :740 - 749.
  • 10MARINO N, MARSHALL JC, STEEG PS. Protein-protein interac- tions: a mechanism regulating the anti-metastatic properties of Nm23-H1 [ J ]. Naunyn Sehmiedebergs Arch Pharmacol, 2011, 384,351 - 362.

共引文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部