丹红注射液改善急性期脑梗死患者的临床疗效及对血管再生的影响

The Clinical Efficacy of Danhong Injection on Acute Cerebral Infarction Based on Vascular Regeneration in Patients with Acute Cerebral Obstruction

目的:探讨丹红注射液对急性期脑梗死患者的临床疗效及对血管再生的影响。方法:选取急性期脑梗死患者60例,随机分为对照组和治疗组,各30例。两组患者均给予抗血小板聚集、脑内压控制等基础治疗,治疗组患者在此基础上给予丹红注射液治疗。分别在治疗前后测定血浆血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(b FGF)水平变化,对比两者临床治疗效果。结果:两组治疗前VEGF和b FGF相比差异无统计学意义(P>0.05),治疗后对照组VEGF无明显改善,差异无统计学意义(P>0.05),治疗组VEGF水平显著提高,差异有统计学意义(P<0.05);治疗后对照组b FGF也无改善,差异无统计学意义(P>0.05),而治疗组b FGF水平显著提高,差异有统计学意义(P<0.01),两组b FGF水平相比差异显著,差异有统计学意义(P<0.01)。对照组治疗后总有效率为43.3%,而治疗组则为73.3%,两组临床疗效相比,差异具有显著统计学意义(P<0.01)。结论:丹红注射液可能通过提高急性脑梗死患者体内VEGF及b FGF的水平,促进血管再生,改善患者临床治疗效果。

Objective To investigate the effect of Danhong injection on clinical efficacy and angiogenesis in patients with acute cerebral infarction. Method Sixty patients with acute cerebral infarction were randomly selected and divided into control group and treatment group according to the principle of random distribution. 30 cases in each group. The patients in both groups were given antiplatelet aggregation,pressure control and other basic treatment,the treatment group of patients on this basis were given Danhong injection treatment. The venous blood of all patients in the second day of admission and 12 days after treatmentwas for plasma vessels Endothelial growth factor（ VEGF） and basic fibroblast growth factor（ b FGF） levels by enzyme-linked immunosorbent assay. Results There was no significant difference between the control group and the treatment group（ P〈0.05）. There was no significant difference between the control group and the control group（ P〈0.05）. The level of VEGF in the treatment group was significantly improved（ P〈0.05）,and the level of b FGF in the treatment group was significantly higher than that in the control group（ P〈0. 01）,and the difference was significant（ P〈0. 01）. The levels of b FGF in the two groups were significantly different（ P〈0. 01）. The total effective rate was 43. 3% in the control group and 73. 3% in the treatment group. The difference was significant（ P〈0. 01）. Conclusion Danhong injection may improve the clinical treatment of patients by increasing the level of VEGF and b FGF in patients with acute cerebral infarction and promoting the regeneration of blood vessels.