甲基泼尼松龙在提高多发性硬化治疗中的临床意义

The significance of intravenous administration of methylprednisolone in the treatment of multiple sclerosis

目的:分析甲基泼尼松龙经静脉给药在提高多发性硬化治疗疗效中的临床意义。方法:选取72例多发性硬化患者为研究对象,数字随机分为对照组(地塞米松治疗)和观察组(甲基泼尼松龙治疗)各36例。对比两组患者在临床疗效、并发症发生率方面的差异。结果:观察组治疗总有效率(88.89%)明显高于对照组(63.89%),两组比较差异有统计学意义(P<0.05)。两组间并发症发生率比较差异无统计学意义(P>0.05)。结论:甲基泼尼松龙治疗多发性硬化的临床疗效确切,可通过调节炎性细胞因子的方式发挥治疗效果,且治疗期间并发症发生率低,用药安全可靠,值得临床推广应用。

Objective To analyze the clinical significance of intravenous administration of methylprednisolone in the treatment of multiple sclerosis. Method 72 patients with multiple sclerosis were selected and randomly divided into control group（ dexamethasone treatment）,observation group（ methylprednisolone treatment）,36 cases in each group. The differences in the clinical efficacy and the incidence of complications in the two groups were compared. Results The total effective rate of 88. 89%in the observation group was significantly higher than that of the control group（ 63. 89%）,and the difference between the groups was significant（ P〈0.05）. There was no significant difference in the incidence of complications between the two groups（ P〈0.05）. Conclusion Methylprednisolone is effective in the treatment of multiple sclerosis. It can play a therapeutic effect by regulating inflammatory cytokines. It has low incidence of complications during treatment,and is safe and reliable. It is worthy of clinical application.