奥拉西坦与吡拉西坦治疗脑卒中后认知功能障碍的随机对照研究

Randomized comparative study of cognitive impairment after cerebral apoplexy with oxiracetam or piracetam

目的:比较奥拉西坦与吡拉西坦治疗脑卒中后认知功能障碍的临床效果。方法:按照随机数字表法将50例脑卒中后认知功能障碍患者均分为观察组和对照组各25例,观察组患者口服奥拉西坦胶囊治疗,对照组患者口服吡拉西坦片治疗,比较两组治疗效果。结果:观察组患者治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后蒙特利尔认知评估量表(Moca)评分、简易精神状态量表(MMSE)评分、生活质量评分和Barthel指数(BI)均显著高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间不良反应发生率对比,差异无统计学意义(P>0.05)。结论:奥拉西坦治疗脑卒中后认知功能障碍效果优于吡拉西坦,在改善患者认知功能、生活质量和日常生活能力方面临床优势明显。

Objective The clinical effect of cognitive impairment compared with Laci Staw oxiracetam in treatment of post stroke. Method 50 cases of cognitive impairment after cerebral apoplexy were randomly divided into observation group（ 25 cases） and control group（ 25 cases）. The observation group were treated with oxiracetam and the control group were treated with piracetam. The clinical effect were observed. Results The total effect of observation group were higher than control group（ P〈0.05）; The Moca score,MMSE score,living quality score and BI score of observation group after treatment were higher than control group（ P〈0.05）; There were no significant difference on the side effect during therapy between the two groups（ P〈0.05）.Conclusion The clinical effect of cognitive impairment after cerebral apoplexy with oxiracetam is better than piracetam. It has obvious clinical advantages in improvement effect of cognitive function,living quality and activity of daily living.