摘要
杏仁核作为边缘系统中参与情绪处理的重要脑区,其功能的异常与精神分裂症的情绪认知及加工功能缺损相关。本文回顾了精神分裂症患者杏仁核结构与功能磁共振成像的研究,分析了二者的变化与精神分裂症患者临床症状的关联性,并进一步探讨了杏仁核相关脑网络的功能异常与精神分裂症患者情绪认知异常的关系。未来的研究可以基于统一的实验范式,分析精神分裂症患者治疗前后杏仁核结构及功能磁共振成像的动态变化,将有助于寻找与疾病诊断和疗效评价、预测有关的影像学指标。
As an important region of emotion regulation in the brain,functional abnormality of amygdala associates with emotional cognitive and processing impairment.This paper reviews the researches about structural and functional magnetic resonance imaging of amygdala,analyzes the correlation between alterations of them and symptoms in schizophrenia and further discusses the relationship between amygdalocortical network and abnormality of emotional cognitive in schizophrenia.Future research could analyze the dynamic changes of structural and functional magnetic resonance imaging of amygdala based on unified experimental paradigm before and after treatment in schizophrenic patients,this would help to search for imaging indicators related to clinical diagnosis and treatment and judgment of prognosis.
作者
张蒙
范丰梅
田占霄
赵艳丽
谭淑平
ZHANG Meng,FAN Fengmei,TIAN Zhanxiao,ZHAO Yanli,TAN Shuping(Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China)
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2018年第6期467-472,共6页
Chinese Mental Health Journal
基金
北京市自然科学基金(7162087)
北京市科技计划项目(Z141107002514016)
关键词
精神分裂症
杏仁核
结构磁共振成像
功能磁共振成像
schizophrenia
amygdala
structural magnetic resonance imaging
functional magnetic resonance imaging
