某中医院消化科323株病原菌的分布及耐药分析

Distribution and Drug Resistance Analysis of 323 Strains of Pathogenic Bacteria in Gastroenterology Department of a TCM Hospital

调查中医院消化科临床常见病原菌的分布及耐药性。回顾分析消化科分离病原菌,病原菌鉴定和药敏实验采用VITEK2分析仪。结果表明:消化科共分离323株病原菌,构成比69.35%为革兰氏阴性菌、26.32%为革兰氏阳性菌、4.33%为真菌。标本以痰液及血液为主,位于前5位的病原菌依次为大肠埃希菌、鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌、表皮葡萄球菌。耐甲氧西林表皮葡萄球菌分离率为76.0%,未检测出耐万古霉素和耐利奈唑胺的葡萄球菌及肠球菌株。肠杆菌科细菌除青霉素、一代头孢耐药率较高外,对其他常用药物耐药率较低。铜绿假单胞菌对氨基糖苷类、碳青酶烯类、喹诺酮类抗菌药及哌拉西林/他唑巴坦的耐药率低于15%。鲍曼不动杆菌表现多重耐药,耐药率高于80%,只有替甲环素、多粘菌素不耐药。消化科细菌耐药情况尚不严重,但需高度重视鲍曼不动杆菌、嗜麦芽窄食单胞菌、耐甲氧西林葡萄球菌的情况,减少耐药菌株的传播。

To investigate the distribution and drug resistance of clinical common pathogenic bacteria in the Gastroenterology Department of TCM hospital.Method：Retrospective analysis of pathogenic bacteria separation of Gastroenterology Department,pathogenic bacteria identification and VITEK2 analyzer used for the drug sensitive test.Result：The Gastroenterology Department separated a total of 323 strains of pathogenic bacteria.The constituent ratio was 69.35% gram-negative bacteria,26.32% gram-positive bacteria and 4.33% fungi.The specimens were mainly sputum and blood,and the first 5 pathogenic bacteria were escherichia coli,acinetobacter baumannii,klebsiella pneumoniae,Pseudomonas aeruginosa,pseudomonas aeruginosa and staphylococcus epidermidis.The separation rate of methicillin-resistant staphycoccus epidermidis was 76.0%,and the staphylococcus and enterococcus strains resistant to vancomycin and linezolid were not detected.Except for penicillin and generation-I cephalosporin,the enterobacteriaceae has low drug resistance rate to other common drugs.The drug resistance rate of pseudomonas aeruginosa to aminoglycosides,carbapenem,quinolones and piperacillin/tazobactam was less than 15%.Except for methacycline and polymyxin,the acinetobacter baumannii showed multi-drug resistance,and the drug resistance rate was higher than 80%.Conclusion：The drug resistance of bacteria in Gastroenterology Department was not serious,but it is necessary to attach great importance to the situation of acinetobacter baumannii,stenotrophomonas maltophilia and methicillin-resistant Staphylococcus,to reduce the spread of drug resistant strains.