PET及MRI评价肿瘤乏氧及下游分子表达的进展

Progresses of PET and MRI in evaluating expression of tumor hypoxic and downstream molecules

实体肿瘤生长导致局部组织缺氧微环境改变,缺氧诱导因子(HIFs)为其中最重要的调节因子。在乏氧情况下,受HIF-1α调控的下游靶基因主要有血管内皮细胞生长因子(VEGF)及葡萄糖转运体1(GLUT-1)基因等。近年来,随着多模态PET及MR成像在肿瘤诊断中的广泛应用,多项研究证实成像所得参数与肿瘤乏氧相关分子的表达存在相关性。本文对PET及多种功能MRI序列检测肿瘤内HIF-1α及其下游的靶基因VEGF及GLUT-1分子表达情况进行综述。

The growth of solid tumors can lead to changes in the hypoxic microenvironment of local tissues,and the most important regulatory factor is the hypoxia-inducible factors（HIFs）.In the case of hypoxia,the downstream target genes regulated by HIF-1αregulation mainly are vascular endothelial growth factor（VEGF）and glucose transporter 1（GLUT-1）genes,etc.In recent years,multimodality PET and MRI imaging technologies have been widely used in diagnosis of tumor diseases,and have confirmed that the parameters obtained by imaging are associated with the expression of tumor hypoxic related molecules.The molecular expression of HIF-1α within the tumor and its downstream target genes VEGF and GLUT-1 detected by PET and multifunctional MRI sequential were reviewed in this article.