CD74及MIF表达对子痫前期巨噬细胞-胎盘滋养层相互作用的影响

Effect of CD74 expression on macrophage-placental trophoblast interaction in preeclampsia

子痫前期是一种较为严重的妊娠期并发症,临床上一般以血压升高为主要表现,伴随蛋白尿等症状,严重者可以危及母婴生命。近年来研究表明该病是由许多因素引起,但是确切病因并未十分明确。巨噬细胞-胎盘滋养层之间相互作用的平衡对于正常妊娠的发生有着重要影响,其中CD74及巨噬细胞迁移抑制因子(MIF)的正常表达对于巨噬细胞-滋养细胞之间的相互作用有着重要的意义,也是目前研究重点之一,本文将对CD74及MIF对子痫前期胎盘巨噬细胞-滋养层之间相互作用的影响进行综述,以期进一步探索该病的发病机制。

Preeclampsia is a serious complication of pregnancy, mainly characterized by hypertension and proteinuria and other clinical manifestations. Severe cases can endanger the lives of mothers and infants. In recent years, studies have shown that preeclampsia is caused by a variety of factors, although the specific cause is not very clear. The balance of placental macrophage-trophoblast interactions plays an important role in the development of normal pregnancy. Normal expression of cluster of differentiation 74（CD74） and MIF plays an important role in the interaction between placental macrophages and trophoblast cells, which is one of the focuses of current research. Here we will review the role of CD74 and MIF in placental macrophage-trophoblast interaction in preeclampsia in order to further explore the pathogenesis of this disease.