信号传导及转录激活因子信号通路在自然杀伤细胞研究中的进展

Research progress of signal transducers and activators of transcription signal pathway in natural killer cell

自然杀伤(natural killer,NK)细胞在机体抗肿瘤免疫、抗感染免疫和生殖免疫中均发挥着重要的作用,对其信号通路的研究有助于更好地理解NK细胞的生物学行为。信号传导及转录激活因子(signal transducers and activators of transcription,STAT)信号通路在NK细胞的生长发育和功能调控中发挥着重要的作用,是近年来研究较多的通路。激活NK细胞内的STAT1、STAT4、STAT5可以促进NK细胞的活性,有利于NK细胞行使其抗感染、抗肿瘤的作用。抑制NK细胞内的STAT3、STAT6亦可增强NK细胞的细胞毒性,但有些情况下会起到相反的作用。作者通过对近几年关于STAT信号通路在NK细胞中研究的调研,旨在促进NK细胞在转化医学中的研究和应用。

Natural killer（ NK） cells play a critical role in anti-tumor immunity,anti-infection immunity and reproductive immunity. The study of its signaling pathway is helpful for us to better understand the biological behavior of NK cells. Signal transducers and activators of transcription（ STAT） signaling pathway is one of the most studied pathways in recent years which plays an important role in the growth,development and functional regulation of NK cells. In this paper,we reviewed the recent progress of STAT signaling pathway in NK cells to promote the application of NK cell in translational medicine.