基于热传导模型的血流灌注率无损量测研究

Study on Nondestructive Measurement of Blood Perfusion Rate Based on Heat Conduction Model

建立了多层皮肤组织的热传导模型,利用有限元方法对模型进行了求解分析,发现当在皮肤组织表面进行常热流量加热时皮肤组织表面最终恒定温度和血流灌注率的大小有关,利用ExpAssoc函数进行拟合得到了二者之间的关系曲线,并且根据此关系曲线设计了血流灌注率无损量测装置,对人体皮肤组织的血流灌注率进行了量测,发现测量结果与计算结果趋势一致,并且和其他文献报道的结果吻合度较高。此方法简单有效,也可应用于其它生物组织血流灌注率的无损量测.

The heat conduction model of multi-layer skin tissue is established, The finite element method is used to solve the model. It was found that, if the skin surface is heated by constant heat flux, the final constant temperature of skin surface is related the blood perfusion rate. Function curve between them is fitted by ExpAssoc function. According to the relation curve, the blood perfusion rate nondestructive measurement device was designed. The perfusion rate of human skin tissue was measured with the device It is found that the measured results are in good agreement with other test results reported in the literature and the calculated results. The method is simple and effective. It can also be used for noninvasive measurement of blood perfusion rate of other biological tissues.