自噬在皮肤鳞状细胞癌发病机制中的研究进展

New Perspectives on Role of Autophagy in Pathogenesis of Cutaneous Squamous Cell Carcinoma

皮肤鳞状细胞癌是皮肤的常见恶性肿瘤之一,其发病机制复杂。自噬在皮肤鳞癌细胞上皮间质转化、信号通路转导、预防紫外线损伤方面发挥重要作用;同时,自噬又可以增强对鳞癌放疗的敏感性,因此与皮肤鳞癌的发展、侵袭与转移关系密切。本文就近年来有关自噬在皮肤鳞癌发病过程中的作用进行综述。

Cutaneous squamous cell carcinoma is one of the most common skin cancers with complicated pathogenesis. Autophagy plays a key role in epithelial-mesenchymal transition,signal transduction,prevention of UV damage; meanwhile,autophagy can enhance sensitivity to radiation therapy in human squamous cell carcinoma. Therefore,there may be a close association between autophagy and the progression,invasion and metastasis in cutaneous squamous cell carcinoma. In this review,we briefly summarized the role of autopahgy in pathogenesis of cutaneous squamous cell carcinoma.