疏肝清毒汤对肝郁型子宫颈癌化疗患者临床疗效、中医证候积分及凝血功能的影响

Effect of Shugan Qingdu Decoction on Clinical Efficacy,TCM Syndrome Scores and Coagulation Function of Cervical Cancer Patients with Liver Depression Syndrome After Chemotherapy

目的:观察疏肝清毒汤对肝郁型子宫颈癌化疗患者临床疗效、中医证候积分及凝血功能的影响。方法:以110例肝郁型子宫颈癌化疗患者为研究对象,所有患者均应用疏肝清毒汤治疗。比较治疗前后患者中医证候积分、不良反应及凝血功能相关指标的变化情况,并对临床疗效进行评价。结果:110例患者的临床有效率为90.91%;与治疗前比较,治疗后患者阴道流血、心烦易怒、胸胁胀痛、口苦咽干、全身窜痛等积分均明显下降,差异有统计学意义(P<0.05);治疗后,患者恶心呕吐、乏力、尿路刺激症、泄泻及便血等不良反应积分均较治疗前显著下降,差异有统计学意义(P<0.05);治疗后患者D-二聚体、纤维蛋白原水平分别为(1.41±0.38)mg·L^(-1)、(3.98±0.72)kg·L^(-1),均低于治疗前的(1.46±0.37)mg·L^(-1)、(4.44±0.98)kg·L^(-1),差异有统计学意义(P<0.05)。结论:对肝郁型子宫颈癌化疗患者采用疏肝清毒汤治疗,可有效改善患者血液高凝状态,缓解临床症状,减轻不良反应,促进患者身体恢复。

Objective：To observe the effect of Shugan Qingdu Decoction on the clinical efficacy,TCM syndrome score and coagulation function of Cervical Cancer patients with Liver Depression Syndrome after chemotherapy. Methods：A total of 110 patients with chemotherapy for cervical cancer with Liver Depression Syndrome were studied. All patients were treated with Shugan Qingdu Decoction. The changes of TCM syndrome scores,adverse reactions,and blood coagulation related parameters before and after treatment were compared,and clinical efficacy was evaluated. Results：The clinical effective rate was 110. 91% in 110 patients. Compared with that before treatment,the scores of vaginal bleeding,upset irritability,chest pain,mouth pain,dry throat and general analgesia decreased significantly after treatment（ P〈0. 05）. After treatment,adverse reactions such as nausea,vomiting,fatigue,urinary tract irritation,diarrhea,and blood in the stool were decreased compared that with before treatment,and the difference was statistically significant（ P〈0. 05）. The levels of D-dimer and fibrinogen were（ 1. 41 ± 0. 38） mg · L-1 and（ 3. 98 ± 0. 72）kg·L-1,respectively,which were lower than those,namely,（1. 46 ± 0. 37） mg·L-1 and（4. 44 ± 0. 98） kg·L-1,before treatment. The difference was statistically significant（ P〈0. 05）. Conclusion： Shugan Qingdu Decoction is effective in treatment of Cervical Cancer patients with Liver Depression Syndrome after chemotherapy,which can effectively improve the blood hypercoagulability state,relieve clinical symptoms,reduce adverse reactions,and promote physical recovery.