督灸治疗职业性尘肺病64例临床研究

Clinical Study on Du Meridian Moxibustion in Treatment of Occupational Pneumoconiosis with 64 Cases

目的:观察督灸治疗职业性尘肺病的临床疗效及其对患者免疫功能的影响。方法:124例尘肺病患者采用随机信封法将患者分为观察组(64例)和对照组(60例)。对照组给予常规止咳、化痰、平喘等对症治疗,观察组在对照组治疗基础上给予督灸,每7天治疗1次,连续5次为1个疗程,每年1个疗程,连续治疗2年。观察尘肺病患者治疗前后临床症状的变化,连续3年合并肺部感染的次数,外周血CD^(4+)/CD^(8+)、自热杀伤(natural killer,NK)细胞以及免疫球蛋白Ig A、Ig G、Ig M水平的变化。结果:观察组有效率为82.81%,对照组有效率为48.33%,两组比较,差异有统计学意义(P<0.01)。治疗后,观察组肺部感染次数少于治疗前及对照组(P<0.01);观察组CD^(4+)/CD^(8+)高于治疗前及对照组(P<0.01);观察组NK细胞低于治疗前及对照组(P<0.05);观察组治疗后Ig A、Ig G均低于治疗前及对照组(P<0.01)。结论:督灸能改善尘肺病患者的临床症状,纠正其免疫功能紊乱状态,调节机体免疫功能,减少合并肺部感染次数。

Objective：To observe the clinical curative effect of Du Meridian moxibustion on occupational pneumoconiosis and its effect on the immune function of patients. Methods：A total of 124 pneumoconiosis patients were randomly divided into an observation group（64 cases） and a control group（60 cases）. The control group was given symptomatic treatment such as routine cough relieving,phlegm-relieving,and anti-asthma treatment. The observation group was given moxibustion in addition to that of the control group. The treatment was performed once every 7 days. 5 times of the treatment was 1 course of treatment. The treatment continued for 2 years. Observe the change of clinical symptoms,the number of consecutive lung infections for three years,peripheral blood CD4＋/CD8＋,natural killer（NK） cells,and immunoglobulin Ig A,Ig G,IgM levels before and after treatment in patients with pneumoconiosis were compared. Results： The effective rate was 82. 81% in the observation group and 48. 33% in the control group. There was a significant difference between the two groups（ P〈0. 01）. After treatment,the number of pulmonary infections in the observation group was significantly lower than that efore treatment and in the control group（ P〈0. 01）. The CD4＋/CD8＋ in the observation group was significantly higher than before treatment and in the control group（ P〈0. 01）. The NK cells in the observation group significantly decreased after treatment and that was significantly lower than that of the control group（ P〈0. 05）.After treatment,the IgA and IgG of the observation group were significantly lower than those before treatment and the control group（P〈0. 01）. Conclusion：Du meridian moxibustion can improve the clinical symptoms of pneumoconiosis patients,correct their immune dysfunction,regulate immunity,and reduce the number of lung infections.