玉液汤治疗气阴两虚型2型糖尿病临床研究

Clinical Study on Yuye Decoction in Treatment of Type 2 Diabetes with Qi and Yin Deficiency Syndrome

目的:观察胰岛素联合玉液汤治疗气阴两虚型2型糖尿病患者的临床疗效,并观察其对患者血糖、血脂及胰岛素分泌的影响。方法:120例气阴两虚型2型糖尿病患者随机分为对照组和观察组,每组各60例。对照组给予胰岛素治疗,观察组在对照组治疗基础上给予玉液汤。两组均治疗1个月。治疗后,比较两组患者临床疗效,血糖、血脂水平,并比较两组患者胰岛素分泌水平。结果:观察组有效率为95.0%,对照组为71.6%,两组比较,差异有统计学意义(P<0.05)。对照组患者治疗前后空腹血糖分别为(10.07±3.59)mmol·L^(-1)、(7.34±1.96)mmol·L^(-1),餐后2小时血糖分别为(17.56±3.67)mmol·L^(-1)、(12.48±2.26)mmol·L^(-1);观察组患者治疗前后空腹血糖分别为(10.13±3.31)mmol·L^(-1)、(6.42±2.73)mmol·L^(-1),餐后2小时血糖分别为(17.59±3.94)mmol·L^(-1)、(11.05±2.10)mmol·L^(-1)。治疗前两组患者空腹血糖、餐后2小时血糖比较,差异无统计学意义(P>0.05);治疗后,对照组和观察组患者空腹血糖、餐后2小时血糖均显著下降,差异均有统计学意义(P<0.05);治疗后,观察组患者空腹血糖、餐后2小时血糖均显著低于对照组(P<0.05)。治疗后,观察组患者胆固醇、三酰甘油、低密度脂蛋白胆固醇明显低于对照组,高密度脂蛋白胆固醇高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组胰岛素分泌水平高于对照组,两组比较,差异有统计学意义(P<0.05)。结论:玉液汤治疗气阴两虚型2型糖尿病疗效显著,可显著降低患者血糖、血脂水平,提高胰岛素分泌水平。

Objective：To observe the clinical efficacy of insulin combined with Yuye Decoction in treatment of type 2 diabetes with Qi and Yin Deficiency Syndrome and to observe its effect on blood glucose,blood lipid and insulin secretion. Methods：One hundred and twenty patients with type 2 diabetes with Qi and Yin deficiency Syndrome were randomly divided into control group and observation group,with 60 cases in each group. The control group was given insulin treatment,and the observation group was given Yuye Decoction in addition to that of the control group. Both groups were treated for 1 month. After treatment,the clinical efficacy,blood glucose,blood lipid levels and insulin secretion were compared between the two groups. Results： The effective rate was95. 0% in the observation group and 71. 6% in the control group. There was a significant difference between the two groups（ P〈0. 05）. The fasting blood glucose levels before and after treatment in the control group were（10. 07 ± 3. 59） mmol·L-1,（7. 34 ±1. 96） mmol·L-1,and the postprandial 2-hour blood glucose was（17. 56 ±3.67） mmol·L-1,（12. 48 ±2. 26）mmol·L-1. The fasting glucose in the observation group was（10. 13 ± 3. 31） mmol·L-1,（6. 42 ± 2. 73） mmol·L-1,and postprandial 2-hour blood glucose was（17. 59 ± 3. 94） mmol·L-1,（11. 05 ± 2. 10） mmol·L-1. There was no significant difference in fasting blood glucose and postprandial blood glucose levels between the two groups before treatment（ P〈0. 05）. After treatment,fasting blood glucose and postprandial blood glucose at 2 hours were significantly decreased in both the control and observation groups（ P〈0. 05）. After treatment,the fasting blood glucose and postprandial blood glucose were significantly lowered in the observation group than that in the control group（ P〈0. 05）. After treatment,cholesterol,triacylglycerol,and low-density lipoprotein in the observation group were significantly lower than those in the control group,and HDL-C was higher than in the control group,with significant differences（ P〈0. 05）. After treatment,insulin secretion was higher in the observation group than in the control group. There was a statistically significant difference between the two groups（ P〈0. 05）. Conclusion：Yuye Decoction is effective in treating for type2 diabetes with Qqi and Yin Deficiency Syndrome,which can significantly reduce blood glucose and blood lipid levels and increase insulin secretion.