外排型转运体与肿瘤多药耐药

Efflux transporters and multidrug resistance in tumors

肿瘤多药耐药(MDR)是导致肿瘤化疗失败的主要原因之一。肿瘤MDR的机制有多种,其中外排型转运体的过表达是导致MDR的主要机制,因此研究外排型转运体介导的肿瘤MDR机制和发现可以逆转肿瘤MDR的抑制剂成为国内外研究的热点。就目前研究的3种三磷酸腺苷结合盒转运体:P-糖蛋白、多药耐药相关蛋白、乳腺癌耐药蛋白介导的MDR及逆转MDR的机制进行综述,以期为提高肿瘤治疗疗效提供依据。

Multidrug resistance（MDR） is one of the major causes of tumor chemotherapy failure. There are many mechanisms of MDR in tumors, in which the overexpression of efflux transporters is the main mechanism leading to MDR. Therefore, it has become a research hotspot at home and abroad to study the mechanisms of tumor MDR mediated by efflux transporter and to find out inhibitors which can reverse the tumor MDR. The current studies on the three kinds of adenosine triphosphate binding cassette transporters： P-glycoprotein, multidrug resistance-associated protein, breast cancer resistance protein-mediated MDR, and reversal mechanism of MDR were reviewed in order to provide basis for improving the therapeutic efficacy of cancer.