抗梅毒治疗对妊娠梅毒患者妊娠结局和围产儿预后的影响

Effect of anti-syphilis treatment on pregnancy outcomes in the patients with syphilis in pregnancy and prognosis of perinatal infants

目的探讨抗梅毒治疗对妊娠梅毒患者妊娠结局和围产儿预后的影响。方法选择2014年1月~2015年1月我院接诊的100例患者进行研究,根据随机数表法随机均分为两组。观察组50例患者进行正规的抗梅毒治疗;对照组50例患者未进行抗梅毒治疗。所有的患者均经过妊娠期梅毒诊断标准,比较两组孕妇的结局和新生儿预后的情况。结果观察组不良妊娠结局发生率为4%,明显低于对照组(36%),两组比较差异有统计学意义(P<0.05);观察组不良新生儿结局发生率为8%,明显低于对照组(34%),两组比较差异有统计学意义(P<0.05);观察组的26例新生儿快速血浆反应素环状卡片试验(Rapid plasma reagin,RPR)全部转阴,明显高于对照组14例(44.12%)转阴,两组转阴率比较差异有统计学意义(P<0.05)。结论在早期发现妊娠梅毒患者并进行规范的抗梅毒治疗,能改善妊娠结局和围产儿预后影响,有效的降低新生儿的死亡和新生儿先天梅毒发生率。

Objective To investigate the effect of anti-syphilis treatment on pregnancy outcome in the patients with syphilis in pregnancy and prognosis of perinatal infants. Methods 100 patients who were admitted to our hospital from January 2014 to January 2015 were selected for the study. They were randomly divided into two groups according to the random number table method. 50 patients in the observation group were given regular anti-syphilis treatment; 50 patients in the control group were not given anti-syphilis treatment. All patients were evaluated by the diagnostic criteria of syphilis in pregnancy. The outcome of the two groups of pregnant women and the prognosis of the newborns were observed and compared. Results The incidence rate of adverse pregnancy outcome in the observation group was 4%,which was significantly lower than that in the control group（36%）. The difference between the two groups was statistically significant（P〈0.05）; the incidence rate of adverse neonatal outcomes in the observation group was 8%, which was significantly lower than that in the control group（34%）. The difference between the two groups was statistically significant（P〈0.05）; Rapid Plasma Reagin（RPR） tests in 26 newborns in the observation group were all negative, significantly higher than 14 negative cases in the control group（44.12%）. There was a statistically significant difference between the two groups in the rate of negative conversion（P〈0.05）. Conclusion The early detection of syphilis in pregnancy and standardized anti-syphilis treatment can improve pregnancy outcomes and perinatal prognosis, which effectively reduces neonatal mortality and the incidence rate of neonatal congenital syphilis.