晚期肺癌患者化疗期间医院感染危险因素分析

Analysis of the risk factors of nosocomial infection during chemotherapy in patients with advanced lung cancer

目的分析晚期肺癌患者化疗期间发生医院感染的危险因素。方法回顾性分析本院2013年6月至2016年6月收治的693例晚期肺癌患者的临床资料,统计医院感染的发生率,分析晚期肺癌患者化疗期间发生医院感染的危险因素。结果693例晚期肺癌化疗患者中,发生医院感染113例,感染率为16.3%;感染发生部位以呼吸道、口腔黏膜、胃肠道为主。年龄≥60岁、住院天数≥30天、中性粒细胞计数<1.5×10~9/L、联合化疗、有侵袭性操作、预防性使用抗菌药物为晚期肺癌患者化疗期间发生医院感染的独立危险因素(P<0.05)。结论导致晚期肺癌患者化疗期间发生医院感染的危险因素较多,临床上需依据相关危险因素采取防控措施,以控制医院感染的发生,改善患者预后,提高其生活质量。

Objective To analyze the risk factors of nosocomial infection during chemotherapy in patients with advanced lung cancer. Method The clinical data of 693 patients with advanced lung cancer admitted to our hospital from June 2013 to June 2016 were retrospectively analyzed. The incidence of nosocomial infection was analyzed. Risk factors for nosocomial infection during chemotherapy in patients with advanced lung cancer were analyzed. Result Among 693 patients with advanced lung cancer in the treatment of chemotherapy, 113 nosocomial infections occurred, and the infection rate was 16.3%. The main sites of infection were respiratory tract, oral mucosa, and gastrointestinal tract. Age ≥ 60 years old, hospitalization days ≥ 30 days, neutrophil count 〈1.5×10^9/L, use of combination chemotherapy, invasive procedures, and prophylactic use of antibiotics were independent risk factors of nosocomial infection in patients with advanced lung cancer during chemotherapy（P〈0.05）. Conclusion The risk factors of nosocomial infection in advanced lung cancer patients during chemotherapy are relatively more. In clinic, prevention and control measures should be taken in order to control the incidence of nosocomial infection, improve the prognosis and life quality of patients.