微小RNA对软骨代谢的影响

Effect of microRNA on metabolism of cartilage

微小RNA(microRNA)是一类非蛋白质类的新型基因表达调控因子。研究发现,miRNA在软骨代谢性疾病发展过程中发挥了重要作用。本文就miRNA生物特性及作用机制,软骨相关miRNA以及骨关节炎相关miRNA的研究进展做一综述。miRNA在软骨发育以及骨关节炎发生、发展过程中参与调节细胞内多种信号通路与炎性因子的表达,部分具有特异性,因此,某些特异性miRNA可以作为疾病的诊断标志物以及治疗靶点应用于临床中。

MicroRNA is a novel type of non-protein gene modulator, and miRNA palys an important role in the regulation of cartilage-associated metabolic diseases through mRNA-associated target genes and signal pathways. This paper reviews the progress of the biological features and mechanisms of miRNA, as well as the miRNAs associated with cartilage and osteoarthritis. Some miRNAs express specifically in cartilage and modulate expression of several signal path-ways and inflammatory factors. Several miRNA could be applied as the marker and therapeutic targets in clinic.