乳腺癌保乳手术联合术中放疗适应证研究进展

Progress of breast-conserving surgery combine intraoperative radiotherapy indication for breast cancer

乳腺癌是居全球女性发病率前列的恶性肿瘤之一,临床常用的全乳腺切除的手术方式,对患者的心理和美容造成很大影响。保乳手术(BCS)联合术中放射治疗(IORT),由于减少了放射治疗周期和周围正常组织放射剂量,同时又保持了良好的肿瘤治疗特异性和较好的美容效果,因此保乳手术联合术中放疗得到了国际上的支持。但是,在IORT患者的选择方面,存在多个意见,但是并未达成共识,甚至其中一些提出了相互矛盾的观点。笔者就乳腺癌保乳手术联合术中放疗适应证相关研究进行综述。以便为临床医生的医疗决策提供借鉴和参考。

Breast cancer is the most common disease in women worldwide, the whole-mammectomy surgery greatly effects on the patients′ psychological and beauty. Breast-conserving surgery（BCS） combined intraoperative radiotherapy（IORT） gained international favor because of its reduction in treatment duration, decreased irradiation of healthy organs,and maintain favorable cancer-specific and better cosmetic outcomes. However, in terms of selecting patients, multiple opinions existed, even some with conflicting recommendations. In this review, the existing patient selection guidelines are summarized and compared, in order to provide reference for clinical doctors′ medical decision-making.