血栓通注射液对不稳定性心绞痛患者血清IL-6及MMP-2的影响

Influence of Xueshuantong Injection on serum IL-6 and MMP-2 in patients with unstable angina pectoris

目的观察血栓通注射液对不稳定性心绞痛患者的临床疗效,并探讨其对白细胞介素-6(IL-6)和基质金属蛋白酶-2(MMP-2)水平的影响及其治疗不稳定性心绞痛的可能的作用机制。方法选取2017年1~10月在邯郸市中心医院心内科住院的不稳定性心绞痛患者120例,按随机数字表法分为对照组和治疗组,每组60例。对照组给予西医常规治疗,治疗组在对照组治疗基础上加用血栓通注射液治疗,连续应用14 d。观察两组患者心绞痛、心电图疗效及治疗前后血清IL-6和MMP-2水平变化。结果治疗组与对照组治疗后心绞痛和心电图疗效均明显改善,前者疗效明显优于后者(P<0.05),两组患者血清IL-6和MMP-2水平与治疗前比较均明显下降(P<0.05),治疗后治疗组患者血清IL-6和MMP-2水平均明显低于对照组(P<0.05)。结论对于不稳定性心绞痛患者,在常规治疗基础上加用血栓通注射液疗效确切,其作用基质可能与其显著降低炎性因子IL-6和MMP-2水平,抑制炎性反应有关。

Objective To observe the effect of Xueshuantong Injection on soluble interlekin-6（IL-6） and matrix metalloproteinase-2（MMP-9） in patients with unstable angina pectoris and its potential mechanism. Methods From January 2017 to October 2017, 120 patients treated in the Department of Cardiology, Handan Central Hospital were divided into control group（n=60） and treatment group（n=60） by random number table. Patients in the control group were treated with routine treatment, and the patients in the treatment group were treated with Xueshuantong Injection based on the control group, they were treated for 14 days. The effects of unstable angina pectoris and electrocardiogram curative were observed. The levels of serum IL-6 and MMP-2 were measured before and after treatment. Results After treatment, the effects of unstable angina pectoris and electrocardiogram curative in the treatment group were significantly higher than those in the control group（P〈0.05）. The levels of serum IL-6 and MMP-2 in the two groups were significantly lower than before treatment（P〈0.05）. The levels of serum IL-6 and MMP-2 in the treatment group were lower than those in the control group after treatment（P〈0.05）. Conclusion Xueshuantong Injection has effect in patients with unstable angina pectoris, which can reduce the levels of serum IL-6 and MMP-2, and inhibit inflammatory reaction.