神经节苷脂治疗儿童病毒性脑炎的效果观察

Clinical effect observation of Gangliosides in children with viral encephalitis

目的研究神经节苷脂治疗儿童病毒性脑炎的效果。方法选择我院2012年1月~2017年12月收治的病毒性脑炎患儿60例,按照入院顺序分为对照组和研究组,每组各30例。对照组采用常规治疗;研究组采用神经节苷脂治疗。对比两组临床症状消失与改善时间、疗效情况与NHP评分情况。结果研究组症状消失时间与恢复时间均显著短于对照组,差异有统计学意义(P<0.05)。研究组临床总有效率为90.00%,显著高于对照组(63.33%),差异有统计学意义(P<0.05)。研究组不良反应发生率、复发率为10.00%、3.33%,明显低于对照组(36.67%、16.67%),且研究组NHP评分情况显著优于对照组,差异均有统计学意义(P<0.05)。结论对儿童病毒性脑炎患儿实施神经节苷脂治疗,可改善儿童临床症状,有效提高儿童生活质量,减轻患儿痛苦,复发率低,值得临床应用及推广。

Objective To explore the clinical efficacy of Gangliosides in children with viral encephalitis.Methods A total of 60 children with viral encephalitis treated from January 2012 to December 2017 in our hospital were selected.The subjects were divided into two groups according to the registration number,30 cases in each group.The control group took the conventional therapy;the study group took the gangliosides.The disappearance time and improvement time of clinical symptoms,clinical effect and NHP（Nottingham Health Profile） points were compared.Results The disappearance time and improvement time of clinical symptoms for study group were significantly shorter than that in the control group（P〈0.05）;the total effective rate for study group（90.00%） was significantly higher than that in the control group（63.33%）（P〈0.05）;the adverse event rate and recurrence rate for study group（10.00%,3.33%） were significantly lower than that in the control group（36.67%,16.67%）（P〈0.05）;the NHP points for study group were significantly better than that for control group,the differences were statistically significant（P〈0.05）.Conclusion For children with viral encephalitis,the Gangliosides can greatly improve the clinical symptoms and life quality,relieve the pain and reduce the recurrence rate.