益生菌和美沙拉嗪治疗炎症性肠病的效果

Effect of Probiotics and Mesalazine in the treatment of inflammatory bowel disease

目的研究益生菌联合美沙拉嗪治疗炎症性肠病的效果以及安全性。方法选取2015年8月~2017年12月我院收治的86例炎症性肠病患者作为研究对象,按照患者入院的先后顺序将其分为两组,每组各43例。对照组患者给予美沙拉嗪治疗,观察组患者给予美沙拉嗪和益生菌治疗。比较两组患者的治疗总有效率、不良反应发生率、不良反应严重程度、炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和干扰素-γ(IFN-γ)]水平及肠道屏障功能指标[尿乳果糖/甘露醇(L/M)]等。结果治疗8周后,观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者用药治疗期间的药物不良反应总发生率比较,差异无统计学意义(P>0.05)。两组患者的不良反应严重程度比较,差异无统计学意义(P>0.05)。治疗8周后,观察组患者的TNF-α、IL-6和IFN-γ水平均低于对照组,差异有统计学意义(P<0.05),观察组患者的L/M水平低于对照组,差异有统计学意义(P<0.05)。结论益生菌联合美沙拉嗪治疗炎症性肠病的效果确切,能够改善患者的肠道屏障功能,缓解炎症反应,缩短治疗疗程,且用药安全性高,值得推广。

Objective To explore the efficacy and safety of Probiotics and Mesalazine in the treatment of inflammatory bowel disease.Methods A total of 86 cases of inflammatory bowel disease patients treated in our hospital from August2015 to December 2017 were selected as subjects.The patients were divided into two groups according to the admission order,and each group was 43 cases.The patients in control group were given Mesalazine,the patients in the observation group were treated with Methalazine and Probiotics.The total effective rate,the incidence of adverse reaction,severity of of adverse reactions,the levels of inflammatory factors（Tumor necrosis factor-α [TNF-α],interleukin-6 [IL-6] and interferon-γ [IFN-γ]） and intestinal barrier function index（urine lactulose/mannitolrate [L/M]） were compared between the two groups.Results After 8 weeks of treatment,the total effective rate of treatment in the observation group was higher than that of the control group,and the difference was statistically significant（P〈0.05）.There was no significant difference in the incidence of adverse drug reactions between the two groups during the treatment（P〉0.05）.There was no significant difference in the severity of adverse reactions between the two groups（P 〉0.05）.After 8 weeks of treatment,the levels of TNF-α,IL-6 and IFN-γ in the observation group were lower than those of the control group,the differences were statistically significant（P〈0.05）.The level of L/M in the observation group was lower than that of the control group,and the difference was statistically significant（P〈0.05）.Conclusion Probiotics combined with Mesalazine is effective in treating inflammatory bowel disease,which can improve intestinal barrier function,relieve inflammatory reaction,shorten treatment course,and with high safety.It is worth promoting.