摘要
创伤 ,包括外科手术性创伤可引起胰岛素抵抗 (insulinresistance,IR)。创伤越严重 ,IR程度越明显。IR导致代谢紊乱 ,严重影响病人术后康复。IR的发生机制尚不完全清楚 ,本文主要就手术创伤后IR的受体后机制包括信号转导、葡萄糖转运、细胞内代谢障碍及细胞因子等方面的研究作一简要综述。
Trauma and surgery can cause insulin resistance(IR). The degree of postoperative insulin resistance is associated with the degree of trauma. Insulin resistance has been shown to be related to metabolic disorder after surgery. It has a bad influence on prognosis. The mechanisms of IR is not clear. In this review,experimental data indicate that insulin signaling,glucose transport,metablic disorder and tumor necrosis factor are associated with mechanisms of postoperative insulin resistance.
出处
《创伤外科杂志》
2002年第5期313-316,共4页
Journal of Traumatic Surgery
基金
国家973项目(G1999054200)
关键词
胰岛素抵抗
手术
创伤
insulin resistance
surgery
trauma
