他汀类药物致肝损伤的临床特征及其防治

Clinical features and treatment of statins-induced liver injury

他汀类药物因其抗炎、调脂的作用目前被广泛用于动脉粥样硬化性疾病,尤其是心脑血管病的一级和二级预防中。然而,其相关不良反应如肌病、横纹肌溶解、肝损伤等屡见报道。本文就他汀类药物致肝损伤的特点、发病机制、监测以及处理等方面做一综述。

Thanks to its anti-inflammatoryand lipid-modulating effect,statins are now widely used in the treatment of atherosclerotic diseases,especially in the prevention of primary and secondary cardio-cerebrovascular disease.However,its related side effects such as myopathy,rhabdomyolysis,and liver injury have been reported repeatedly.This article reviews the characteristics,pathogenesis,monitoring and the treatment of statins-induced liver injury.