氟桂利嗪与阿司匹林联合应用治疗偏头痛性脑梗死

Therapeutic effects of flunarizine combined with aspirin on patients with migrainous cerebral infaction

目的 :探讨钙离子拮抗剂氟桂利嗪与抗血小板药阿司匹林联合应用治疗偏头痛性脑梗死的临床疗效。方法 :对诊断明确的 38例偏头痛性脑梗死患者给予氟桂利嗪 10mg与阿司匹林 10 0mg联合治疗 ,两药均每晚一次 ,连用 1mon。观察用药前后患者神经功能缺损程度评分及患者总的生活能力等级的改变 ,同时检测用药前后患者的血小板聚集指数、血浆粘度的变化。结果 :38例用药治疗前患者神经功能缺损程度评分及患者总的生活能力等级分别为13.5 1± 4 .78分与 3.4 5± 1.13级 ,用药后分别为4 .34± 1.85分与 1.79± 0 .72级 ,治疗前后有显著性差异 (P <0 .0 1)。用药前血小板聚集指数与血浆粘度分别为 5 7.1± 19.8与 1.72± 0 .11,用药后分别为35 .12± 7.94与 1.70± 0 .11,治疗前后亦有显著性差异 (P <0 .0 1)。结论 :钙离子拮抗剂氟桂利嗪与抗血小板药阿司匹林联合应用治疗偏头痛性脑梗死有较好的的临床效果 ,值得临床推广。

AIM: To explore the therapeutic effects of flunarizine combined with aspirin in the treatment of migrainous cerebral infaction. METHODS: 38 cases of patients diagnosed as migrainous cerebral infaction were respectively given flunarizine 10 mg combined with aspirin 100 mg every night for a month. The observed indices included the dysfunction scores of nervous system, the total classes of living ability, and the accumulating rate of platelet and viscosity of plasma before and after the treatment. RESULTS: Before the treatment the dysfunction scores of nervous system and the living ability of the patients were 13.51 ± 4.78 and 3.45 ± 1.13 , and after the treatment the values were 4.34 ± 1.85 and 1.79 ± 0.72 respectively (P< 0.01 ). The accumulating rate of platelet and viscosity of plasma were 57.1 ± 19.8 and 1.72 ± 0.11 before the treatment, and the values were 35.12 ± 7.94 and 1.70 ± 0.11 respectively (P< 0.01 ) after the treatment. CONCLUSION: Flunarizine combined with apirin shows a significant therapeutic effect in treatment of migrainous cerebral infaction.