摘要
目的 :研究心肌梗死急性期经皮给予小剂量东莨菪碱能否增加心脏迷走神经的张力。方法 :6 8例首次急性心肌梗死 (AMI)患者 ,窦性心律 ,未用任何影响窦房结的药物 ,随机分为东莨菪碱组和安慰组 ,双盲法给药。治疗前后用数字化 2 4hHolter记录测定心率变异性时域参数和频域参数。用苯肾上腺素法测定压力反射敏感性。结果 :治疗前心率变异性参数和压力反射敏感性在两组间无明显差异。经皮东莨菪碱治疗明显增加心率变异的时域参数 ,包括RR间期标准差均值 (SDNN) ,RR间期均值标准差 (SDANN )和相邻RR间期差值的均方根(rMSSD) ,以及频域参数 ,包括总功率谱 (TP ,0～ 0 .4 0Hz)、低频 (LF ,0 .0 4～ 0 .15Hz)和高频 (HF ,0 .15～0 .4 0Hz)及压力反射敏感性。结论 :心肌梗死急性期应用小剂量东莨菪碱透皮治疗可显著增加心脏迷走神经压力 ,改善自主神经失衡。
AIM: To investigate whether transdermal scopolamine increased cardiac vagal activity in patients with acute myocardial infarction. METHODS: A random, double blind, and placebo contrast trial was performed. Measures of heart rate variability (HRV) in patients given drugs or placebo were obtained by electrocardiograph and digital 24 h Holter recording before and after treatment. Baroreflex sensitivity (BRS) was performed using the phenylephrine method. RESULTS: Patients of acute myocardial infarction with transdermal scopolamine showed a significant increase in HRV time domain parameters and BRS after treatment (P<0.05). CONCLUSION: Low doses of transdermal scopolamine increased cardiac vagal activity improves autonomic indices in patients with acute myocardial infarction.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2002年第5期409-411,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
河南省科技攻关基金资助项目 (№ 95 12 0 0 2 19)
